Quantum Cascade Laser Spectral Histopathology: Breast Cancer Diagnostics Using High Throughput Chemical Imaging
Using a first-generation Spero QCL microscope, researchers at the University of Manchester accurately differentiated between four different malignant and non-malignant histological classes of an independent population set of 207 breast cancer patients. The study established that large tissue microarrays (TMAs) can be spectroscopically imaged within minutes instead of hours while achieving accurate disease segmentation using wide-field QCL imaging. This high-throughput, high-accuracy and label-free histological protocol could revolutionize histopathology by significantly reducing accurate diagnostic times and simplifying the pathology workflow.
Defects and Deformation of Boron Nitride Nanotubes Studied by Joint Nanoscale Mechanical and Infrared Near-Field Microscopy
Boron nitride nanotubes (BNNTs) are a one-dimensional material with interesting mechanical and physical properties. Researchers at the University of Toronto and Lehigh University used a Daylight Solutions MIRcat laser for infrared scattering near-field microscopy and nanomaterial characterization to study defects and deformations in the BNNTs and their impact on the mechanical properties. These studies revealed that the BNNTs have polygonal facets, which implies that these nanotubes should have a range of reactive chemical and hyperbolic optical properties.
Real-time breath analysis is a promising, non-invasive tool in medical diagnostics and has been used to study a variety of health biomarkers. In this study, researchers at Umea University in Sweden investigated the physiology of CO as a biomarker for respiratory disease and oxidative stress using a Daylight Solutions mode-hop-free tunable laser. Real-time detection using the laser was confirmed by comparison to expirograms measured by capnography. It was found that eCO expirograms have a strong dependence on exhalation flow rate and breath-holding times. This new sensor opens ways to study physiology and toxicology and may provide ways to distinguish between different endogenous and exogenous sources of eCO.
Bullseye® Apodizing filters are customizable density gradient filters that change radially from the center to the outside of the optical component. These filters are used to eliminate undesirable intensity variations in optical systems or to modify the wavefront of an optical source. Bullseye® filters come in two configurations, normal and inverse apodizing.
Cobolt AB have received the largest order so far for the year for an unanticipated application. The Indian fishing authorities have placed an order for an undisclosed number of Cobolt Samba™ 25 mW lasers. The Cobolt Samba™ lasers have the perfect weight, size and splash to attract the largest of Tunis Albacares (Yellow fin tunas).
Cost‐effective and robust spectral sensor technology -
Fast milk fat content analysis to process and hand‐held applications -
- In‐situ reflectance measurement with fiber optical probe
In this article, we discuss several applications of SWIR (short-wave infrared) cameras in semiconductor inspection applications. Most of these applications rely on the capability of SWIR cameras to see through semiconductor materials such as silicon.
In this article, we introduce adaptive optics and focus on the advantages of using (short-wave) infrared cameras in wavefront sensing. We also highlight some key applications in astronomy, laser communication, biological imaging microscopy and retinal imaging in combination with optical coherence tomography. We conclude with the key performance parameters of SWIR cameras used in adaptive optics applications.
Mid-IR lasers continue to help push boundaries in many cutting-edge applications. Here are some recently published articles using Daylight Solutions’ QCL lasers that we thought you might find interesting. These are just some of the most recent of the over 140 publications using the Daylight Solutions lasers.